Malegra 100 contains sildenafil citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor. The primary target of sildenafil in the body is the smooth muscle tissue in the corpus cavernosum of the penis. The corpus cavernosum is a pair of sponge-like tissue structures within the penis that become engorged with blood during sexual arousal, leading to an erection. During sexual arousal, the release of nitric oxide in the corpus cavernosum activates an enzyme called guanylate cyclase. This enzyme increases the production of cyclic guanosine monophosphate (cGMP). cGMP is responsible for relaxing the smooth muscles in the walls of the blood vessels within the penis, allowing them to dilate. As the smooth muscles relax, the blood vessels widen, allowing increased blood flow into the penis. This influx of blood engorges the erectile tissue, leading to an erection. Sildenafil in Malegra 100 works by inhibiting the action of phosphodiesterase type 5 (PDE5), an enzyme that breaks down cGMP. By inhibiting PDE5, sildenafil helps to maintain higher levels of cGMP in the corpus cavernosum, prolonging the relaxation of smooth muscles and enhancing the vasodilatory effects, resulting in improved blood flow to the penis.,It's important to note that the effects of Malegra 100 are dependent on sexual stimulation. In the absence of sexual arousal, the medication is unlikely to cause an erection. Additionally, the effectiveness of the medication can vary among individuals, and the appropriate dosage should be determined by a healthcare provider based on the patient's medical history and individual response to the drug.
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