Decoding Glycosylation: A Critical Focus in Early-Stage Biotherapeutic Development
Glycosylation, one of the most intricate post-translational modifications, has emerged as a cornerstone in the research phase of therapeutic protein development. Particularly for monoclonal antibodies and glycoproteins, the structural diversity of glycans can dramatically influence protein behavior, affecting everything from pharmacodynamics to immunogenicity. As researchers look to optimize therapeutic efficacy, understanding the nuances of glycosylation becomes indispensable.