Rivaroxaban application, thromboembolic disease treatment, DVT prevention, VTE therapy, nonvalvular atrial fibrillation treatment, FXa inhibitor, anticoagulant
Rivaroxaban is a prescription medicine for treatment of thromboembolic diseases mainly used to treat and prevent the symptoms of the deep vein thrombosis (DVT) prior to hip or knee replacement surgery, treat the venous thromboembolism (VTE) and nonvalvular atrial fibrillation, and treat DVT and pulmonary embolism (PE).
The action mechanism of rivaroxaban for treatment of thromboembolic diseases can briefly describe as follow: Rivaroxaban is a selective inhibitor of FXa, it does not require a cofactor (such as Anti-thrombin III) for activity and can directly inhibit both free and bound factor FXa in the prothrombinase complex. By inhibiting FXa, rivaroxaban decreases thrombin generation, interrupts the intrinsic and extrinsic pathway of the blood coagulation, and then it inhibits the thrombin as well thrombi formation.
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