Manforce 100 mg contains Sildenafil Citrate, a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction. In healthy individuals, the liver helps metabolize Sildenafil, allowing the drug to be processed and eliminated from the body effectively. However, in people with liver disease, especially moderate to severe liver impairment, this process is altered.
Liver disease reduces the liver’s ability to break down Sildenafil efficiently, leading to higher concentrations of the drug in the bloodstream for a longer period. This can increase both the effectiveness and the risk of side effects, such as headache, flushing, dizziness, low blood pressure, or prolonged erections (priapism).
In patients with mild liver impairment, a standard dose may still be used with caution. However, for those with moderate to severe liver disease, doctors typically recommend lower doses to avoid potential toxicity or severe side effects. Clinical studies suggest that Sildenafil’s clearance is significantly reduced in hepatic impairment, necessitating dose adjustments.
Therefore, individuals with liver disease should not take MANFORCE 100 MG without medical supervision. A healthcare provider will assess liver function and determine the appropriate dosage, if any, to ensure safe and effective treatment. Self-medication in such cases can pose serious health risks.
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