Malegra DXT can cause headaches as a common side effect. This is due to the way its active ingredients affect blood flow. Sildenafil citrate (for erectile dysfunction) Duloxetine (an antidepressant that also treats premature ejaculation) Both of these drugs can independently cause headaches, and when combined, the risk may increase. It dilates blood vessels by increasing nitric oxide and cGMP. This vasodilation can lead to increased pressure or changes in blood flow in the brain, triggering headaches. Duloxetine: It affects levels of serotonin and norepinephrine, which can also influence headache pathways, especially when starting or adjusting the dose. Sildenafil-related headaches occur in up to 16% of users, depending on dose. Duloxetine can also cause headaches, Malegra DXT in the first few days of use. Take it with water and avoid alcohol, which can worsen headaches. Stay hydrated, as dehydration can intensify side effects. You can ask your doctor if a lower dose or splitting components (using sildenafil and duloxetine separately) is better tolerated. For mild headaches, acetaminophen or ibuprofen is usually safe — but check with a doctor to confirm it won’t interfere with your other meds or conditions.
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