Extra Super Tadarise (tadalafil + dapoxetine) can be used with other ED drugs—but only with extreme caution and under medical supervision. Here's what the evidence A clinical study found dapoxetine does not significantly affect tadalafil or sildenafil levels, and vice versa. While sildenafil increased dapoxetine exposure by ~22%, this was deemed not clinically meaningful Both tadalafil and dapoxetine lower blood pressure. Combining them with other PDE‑5 inhibitors (e.g., sildenafil) can amplify this effect, causing dizziness, Extra Super Tadarise , fainting, or even syncope Drugs.com . Approved information warns that using tadalafil and sildenafil together may cause excessive BP drop and increased side effects (headache, flushing, priapism) Some doctors prescribe low-dose daily tadalafil plus occasional sildenafil. Reddit users report this works, but others strongly warn it’s unsafe due to hypotension risk Pharmacologically, no serious drug–drug interactions, but blood pressure effects are cumulative. Never combine multiple PDE‑5 inhibitors or add nitrates/alpha-blockers without doctor oversight—could cause dangerous hypotension. If combining, use low doses, space timing (e.g., daily tadalafil + sildenafil before activity), and monitor blood pressure. Always consult a healthcare provider—especially if you have heart disease or take BP medications.
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