Malegra Pro 100 mg contains sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor primarily used to treat erectile dysfunction in men. Its primary mechanism of action involves enhancing smooth muscle relaxation in the corpus cavernosum of the penis by increasing the levels of cyclic guanosine monophosphate (cGMP).
During sexual stimulation, nitric oxide (NO) is released in the penile tissue. NO activates the enzyme guanylate cyclase, which increases cGMP production. This biochemical pathway leads to relaxation of the smooth muscle cells and vasodilation of the penile arteries, resulting in increased blood flow and erection. Malegra Pro inhibits PDE5, the enzyme responsible for breaking down cGMP, thereby prolonging its action and enhancing the relaxation of smooth muscles.
Although the primary site of action is penile tissue, PDE5 is also present in other smooth muscle-containing organs, such as the lungs and vascular system. Therefore, sildenafil may also cause mild relaxation of smooth muscles in these areas, leading to potential side effects like flushing, headache, nasal congestion, and dizziness due to systemic vasodilation.
In summary, MALEGRA PRO 100 MG promotes smooth muscle relaxation by enhancing the nitric oxide–cGMP pathway, mainly in penile tissues, thereby improving erectile function through improved blood flow.
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